\n
Older women face a lower chance of fertility treatment working, even when using young donor eggs – with a marked drop-off from around the age of 49, new research suggests. <\/b><\/p>\n
Experts studying 1,774 women say the findings challenge the idea that donor eggs can fully “reset” the reproductive clock, but should not put older couples off trying.<\/p>\n
Women aged 49 and over had double the risk of miscarriage than those aged 35 to 40, and were also less likely to get pregnant.<\/p>\n
Researchers believe age-related changes in the womb lining may be the cause and could be treatable in the future. <\/p>\n
It might be possible to find ways to predict, prevent or improve womb age, they say.<\/p>\n
Lead researcher Dr Beatrice Crestani, from an assisted reproduction medical institute in Italy, external<\/span>, says that reproductive ageing has been seen as an ovarian issue, and that if you replace older eggs with younger donor ones, you “reset” the reproductive clock. <\/p>\n“Our findings suggest the picture is more complex,” adds Dr Crestani. <\/p>\n
In the study, women in their mid to late 30s had a 54% chance of getting pregnant with donor eggs and IVF treatment; that fell to around 43% for those aged 49 or older. <\/p>\n
Live birth rates declined from 46% to 32%, while miscarriage rates increased from 24% to 38%.<\/p>\n
The researchers also noticed age-related changes to the womb lining or endometrium – where a fertilised egg or embryo implants to grow – in the older women. <\/p>\n
While the thickness was similar, the condition declined with age.<\/p>\n
Dr Crestani added: “These findings should not discourage women from pursuing donor-egg treatment, because success rates remain meaningful even at advanced ages.<\/p>\n
“However, patients should be counselled that donor eggs cannot completely eliminate the effects of reproductive ageing, particularly beyond 49 years.”<\/p>\n
In the study, the live birth rate was around 80% for women aged 35-40 and 62.5% among those aged 49 or older who transferred all available embryos.<\/p>\n<\/div>\n
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