In a report released Wednesday, UNICEF highlighted the growing threat of cholera in the war-torn country, with more than 7,700 cases and 185 associated deaths reported in Khartoum State alone since January 2025. Alarmingly, over 1,000 cases have affected children under the age of five.

Since the onset of conflict in April 2023, three million people have been forced to flee their homes, displaced internally and across the region.

Returning to homes without water

While improved access to parts of Khartoum State has enabled more than 34,000 people to return since January, many are coming back to homes that have been severely damaged and lack access to basic water and sanitation services.

Recent attacks on power infrastructure in Khartoum State have compounded the crisis, disrupting water supplies and forcing families to collect water from unsafe, contaminated sources.

This significantly increases the risk of cholera, particularly in densely populated areas such as displacement camps.

UNICEF has implemented a multi-pronged approach to the crisis, including distributing household water treatment chemicals, delivering over 1.6 million oral cholera vaccines, supplying cholera treatment kits, and more.

“Each day, more children are exposed to this double threat of cholera and malnutrition, but both are preventable and treatable, if we can reach children in time,” said Sheldon Yett, UNICEF Representative for Sudan.

Malaria and new prevention efforts

Also on Wednesday, UNICEF launched a partnership with the Sudanese government’s health ministry and The Global Fund to Fight AIDS, Tuberculosis and Malaria to distribute nearly 15.6 million insecticide-treated bed nets to prevent the spread of malaria among vulnerable families across Sudan, along with 500,000 additional nets for antenatal and immunization facilities.

The campaign aims to protect 28 million Sudanese across 14 states.

As with cholera, ongoing conflict and displacement have created conditions conducive to the spread of malaria. Overcrowded and unsanitary living conditions, coupled with the approaching rainy season, present a serious health risk to millions, particularly those returning to damaged communities.

In addition, the initiative aims to bolster the availability of anti-malarial medications, rapid diagnostic tests, and investments in strengthening the healthcare system.

Critical medical supplies reach West Darfur

In a more positive development, the World Health Organization (WHO) announced Tuesday that El Geneina Hospital in West Darfur has received eight tonnes of medical supplies for nutrition, non-communicable diseases and mental health.

The delivery, supported by the World Bank Africa, the Share Project, and the European Union, is expected to sustain the hospital’s operations for six months, providing vital support to one of the regions hardest hit by the multiple escalating crises.

Mosquitoes should be given malaria drugs to clear their infection so they can no longer spread the disease, say US researchers.

Malaria parasites, which kill nearly 600,000 people a year, mostly children, are spread by female mosquitoes when they drink blood.

Current efforts aim to kill mosquitoes with insecticide rather than curing them of malaria.

But a team at Harvard University has found a pair of drugs which can successfully rid the insects of malaria when absorbed through their legs. Coating bed nets in the drug cocktail is the long-term aim.

Sleeping under a bed net has been one of the most successful ways of preventing malaria as the main malaria-spreading mosquitoes hunt at night.

Vaccines to protect children living in high-risk malaria areas are also recommended.

Nets are both a physical barrier and also contain insecticides which kill mosquitoes that land on them.

But mosquitoes have become resistant to insecticide in many countries so the chemicals no longer kill the insects as effectively as they used to.

“We haven’t really tried to directly kill parasites in the mosquito before this, because we were just killing the mosquito,” says researcher Dr Alexandra Probst, from Harvard.

However, she says that approach is “no longer cutting it”.

The researchers analysed malaria’s DNA to find possible weak spots while it is infecting mosquitoes.

They took a large library of potential drugs and narrowed it down to a shortlist of 22. These were tested when female mosquitoes were given a blood-meal contaminated with malaria.

In their article in Nature, the scientists describe two highly effective drugs that killed 100% of the parasites.

The drugs were tested on material similar to bed nets.

“Even if that mosquito survives contact with the bed net, the parasites within are killed and so it’s still not transmitting malaria,” said Dr Probst.

“I think this is a really exciting approach, because it’s a totally new way of targeting mosquitoes themselves.”

She says the malaria parasite is less likely to become resistant to the drugs as there are billions of them in each infected person, but less than five in each mosquito.

The effect of the drugs lasts for a year on the nets, potentially making it a cheap and long-lasting alternative to insecticide, the researchers say.

This approach has been proven in the laboratory. The next stage is already planned in Ethiopia to see if the anti-malarial bed nets are effective in the real world.

It will take at least six years before all the studies are completed to know if this approach will work.

But the vision is to have bed nets treated with both anti-malaria drugs and insecticide so that if one approach doesn’t work, then the other will.

A similar story has happened before. The parasite became resistant to a previous drug – chloroquine – in East Africa in the 1970s, and resistance reached the west coast by the 1980s.

Malaria deaths on the continent trebled from about 493,000 in 1980 to 1.6 million by 2004.

“I’m hoping this is not something we will see in Africa,” Dr Dhorda told me.

“If artemisinin combination therapy starts failing, then cases and deaths will go up.”

The authors have made a series of recommendations targeting both the parasite and the mosquitoes that spread the disease.

They suggest adding a third drug to the artemisinin combination therapy to make it harder for the parasite to evolve resistance to therapy.

Dr Dhorda says this will cost money but: “We might spend a little more now, but if not we’ll be spending a lot more to control the fire rather than putting it out before it became widespread.”

They also call for:

“We ask funders, specifically the Global Fund to Fight Aids, Tuberculosis and Malaria and the US government’s President’s Malaria Initiative, to be visionary and to step up funding for malaria control and elimination programmes to contain the spread of artemisinin resistance in Africa,” said Ntuli Kapologwe, director of preventive services at the Ministry of Health in Tanzania.