The massive Israeli attack happened at about 04:00 local time (02:00 GMT) on Saturday, and the explosions shook the city.
In the dark, emergency teams searched the site in Basta, a densely populated area.
Footage showed a plume of smoke rising from a huge crater after one building collapsed.
In recent months, Israeli air strikes have killed several top Hezbollah members in Beirut, including the group’s leader Hassan Nasrallah.
The Israel Defense Forces (IDF) began a major offensive against Hezbollah in September, carrying out air strikes and also sending troops into southern Lebanon.
The hostilities escalated after the Iran-backed Hezbollah fired repeated salvoes of rockets into Israel in solidarity with Hamas, the Palestinian group that carried out the deadly 7 October 2023 attack on southern Israel.
Israel’s stated goal in its war against Hezbollah is to allow the return of about 60,000 residents who have been displaced from communities in northern Israel because of the group’s attacks.
In Lebanon, the conflict has killed more than 3,500 people and forced more than one million from their homes, Lebanese authorities say.
Earlier this week, a US mediator visited both Israel and Lebanon in an attempt to secure a ceasefire.
Amos Hochstein indicated some progress had been made – but has not publicly commented on any details.
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